LRRC57

Across TCGA pan-cancer cohorts, LRRC57 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of LRRC57’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LRRC57 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LRRC57 is over-expressed in tumor, although a few such as LUAD and KIRC show the opposite, repressed pattern.

HNSC, BLCA, and LIHC are the cancer types where LRRC57 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LRRC57 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+0.978	<.001	12	view →
BLCA	Male	All	+0.607	<.001	9	view →
LIHC	Female	II,III,IV	+0.659	<.001	7	view →
LUAD	Female	II,III,IV	−0.527	<.001	7	view →
KIRC	Male	II,III,IV	−0.427	<.001	6	view →
CHOL	Male	All	+1.390	<.001	5	view →
STAD	All	II,III,IV	+0.726	<.001	4	view →
KICH	All	All	−0.297	.014	2	view →
ESCA	Female	All	+0.413	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

LRRC57–HNSC

Open the HNSC breakdown →