LRRC57

Across TCGA cell cohorts, LRRC57 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,765 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LRRC57-associated GO terms across cancer lineages are Ubiquitin-dependent protein catabolic process via the N-end rule pathway, Circadian sleep/wake cycle, and Regulation of cell cycle checkpoint. Each is linked with LRRC57 in more than 15 cancer types. Because this analysis shows association rather than direction, both LRRC57-to-partner and partner-to-LRRC57 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ubiquitin-dependent protein catabolic process via the N-end rule pathway grouped by LRRC57-low versus LRRC57-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC57→partner) and Y-score (partner→LRRC57) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Ubiquitin-dependent protein catabolic process via the N-end rule pathway →	+0.109	+0.965	<.001	<.001	3	16
CNS	Circadian sleep/wake cycle →	+0.187	+0.638	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Regulation of cell cycle checkpoint →	+0.104	+0.905	<.001	<.001	3	14
OVARY	Regulation of translation at postsynapse, modulating synaptic transmission →	+0.114	+0.789	<.001	<.001	3	14
OVARY	Negative regulation of syncytium formation by plasma membrane fusion →	+0.088	+0.568	.001	.006	3	11
PANCREAS	Regulation of translation at postsynapse →	+0.093	+0.585	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,765 associations by consensus.

Ubiquitin-dependent protein catabolic process via the N-end rule pathway by LRRC57 expression — OESOPHAGUS

Explore this box plot interactively →