LRRC52

Across TCGA cell cohorts, LRRC52 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRRC52-associated genes across cancer lineages are C1QTNF7, DEFA4, and PATE4. Each is linked with LRRC52 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC52-to-partner and partner-to-LRRC52 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1QTNF7 grouped by LRRC52-low versus LRRC52-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC52→partner) and Y-score (partner→LRRC52) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C1QTNF7 →	+0.115	+3.523	<.001	.002	3	1
LARGE_INTESTINE	DEFA4 →	+0.022	+3.700	<.001	.009	3	1
LARGE_INTESTINE	PATE4 →	+0.027	+2.925	<.001	.007	3	1
LARGE_INTESTINE	OR6Q1 →	+0.012	+3.700	<.001	.009	3	1
SKIN	HTR1E →	+0.036	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

C1QTNF7 by LRRC52 expression — LARGE_INTESTINE

Explore this box plot interactively →