LRRC52

Across TCGA pan-cancer cohorts, LRRC52 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated LRRC52 data layer compared with 4 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher LRRC52 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LRRC52 expression acts as an unfavorable survival marker, although some lineages such as OV and SCLC show a favorable association.

UVM, COAD, and OV are the cancer types where LRRC52 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.400	0.778	.001	74	view →
COAD	OS	Tertile	III,IV	0.221	0.704	<.001	72	view →
OV	OS	Quartile	All	0.414	0.285	.003	68	view →
UCEC	DFS	Tertile	III,IV	0.386	0.697	.007	38	view →
LUSC	DFS	Quartile	II,III,IV	0.402	0.658	<.001	29	view →
ACC	DFS	Tertile	II,III,IV	0.175	0.571	.004	27	view →
SCLC	OS	Median	All	1.000	0.418	.001	26	view →
LUAD	OS	Median	All	0.459	0.281	.007	25	view →
LAML	DFS	Tertile	All	0.137	0.431	.034	18	view →
LGG	OS	Median	All	0.942	0.849	<.001	16	view →
SKCM	DFS	Quartile	All	0.301	0.196	.005	14	view →
KIRP	DFS	Tertile	All	0.936	0.668	.036	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

LRRC52–UVM (DFS)

Open the UVM breakdown →