LRRC52

Across TCGA pan-cancer cohorts, LRRC52 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of LRRC52’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LRRC52 RNA is repressed in tumor relative to normal tissue. In most cancer types LRRC52 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and THCA are the cancer types where LRRC52 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LRRC52 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.214	<.001	9	view →
KIRP	Male	II,III,IV	−1.200	<.001	9	view →
THCA	Female	III,IV	+0.875	<.001	9	view →
COAD	All	All	−0.044	.001	7	view →
LUSC	Male	II,III,IV	−1.102	<.001	6	view →
UCEC	All	All	+0.520	<.001	6	view →
STAD	All	All	−0.138	.003	6	view →
LUAD	Male	All	−0.650	.003	5	view →
LIHC	All	All	+0.239	.002	4	view →
BRCA	All	IV	+0.190	.024	4	view →
READ	All	All	−0.076	.010	2	view →
BLCA	All	IV	−0.055	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

LRRC52–KIRC

Open the KIRC breakdown →