LRRC43

Across TCGA patient cohorts, LRRC43 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC43-associated genes across cancer lineages are 4E-BP1, ATM, and Caspase-7-cleavedD198. Each is linked with LRRC43 in more than 3 cancer types. Because this analysis shows association rather than direction, both LRRC43-to-partner and partner-to-LRRC43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by LRRC43-low versus LRRC43-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC43→partner) and Y-score (partner→LRRC43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.213	+2.614	.029	.005	3	4
UCEC	ATM →	-0.384	-1.700	.018	.042	3	3
UCEC	Caspase-7-cleavedD198 →	+0.588	+1.604	.005	.041	3	3
UCEC	C-Raf →	+0.120	+1.807	.019	.025	3	3
UCEC	mTOR_pS2448 →	-0.143	-2.886	.007	.001	3	2
UCEC	PCNA →	+0.277	+3.584	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

4E-BP1 by LRRC43 expression — UCEC

Explore this box plot interactively →