LRRC39

Across TCGA patient cohorts, LRRC39 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC39-associated genes across cancer lineages are 14-3-3_beta, eIF4E, and JNK2. Each is linked with LRRC39 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC39-to-partner and partner-to-LRRC39 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by LRRC39-low versus LRRC39-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC39→partner) and Y-score (partner→LRRC39) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.096	-3.143	.024	.018	3	2
UCEC	eIF4E →	+0.200	+2.222	.025	.011	3	1
UCEC	JNK2 →	+0.243	+3.196	.004	.009	3	1
UCEC	MEK1 →	+0.426	+2.700	.006	.006	3	1
UCEC	p62 Lck ligand →	+0.384	+3.331	.005	.005	3	1
UCEC	PRAS40_pT246 →	+0.187	+1.713	.010	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

14-3-3_beta by LRRC39 expression — UCEC

Explore this box plot interactively →