LRRC39

Across TCGA pan-cancer cohorts, LRRC39 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of LRRC39’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LRRC39 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LRRC39 is over-expressed in tumor, although a few such as HNSC and BRCA show the opposite, repressed pattern.

KIRC, HNSC, and LIHC are the cancer types where LRRC39 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LRRC39 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	+0.383	<.001	10	view →
HNSC	Male	All	−1.524	.002	8	view →
LIHC	All	All	+0.347	<.001	7	view →
STAD	All	All	+0.386	.002	4	view →
CHOL	All	All	+0.928	<.001	3	view →
KIRP	All	All	+0.482	.030	2	view →
BRCA	Female	All	−0.200	.029	2	view →
KICH	All	All	+0.350	.012	1	view →
BLCA	Female	IV	+0.306	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

LRRC39–KIRC

Open the KIRC breakdown →