LRRC39

Across TCGA pan-cancer cohorts, LRRC39 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated LRRC39 data layer compared with 5 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher LRRC39 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated LRRC39 expression acts as an unfavorable survival marker, although some lineages such as BLCA and KIRP show a favorable association.

UVM, BLCA, and CESC are the cancer types where LRRC39 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	III,IV	0.393	0.901	.001	76	view →
BLCA	OS	Tertile	II,III,IV	0.688	0.501	.002	70	view →
CESC	DFS	Tertile	All	0.750	0.894	<.001	58	view →
KIRC	DFS	Quartile	III,IV	0.288	0.621	.001	49	view →
LGG	DFS	Median	All	0.647	0.823	<.001	37	view →
PRAD	DFS	Median	All	0.842	0.927	.002	26	view →
KIRP	OS	Tertile	All	0.799	0.615	.018	23	view →
READ	DFS	Median	IV	0.359	0.827	<.001	18	view →
LIHC	DFS	Median	All	0.341	0.532	<.001	18	view →
UCS	DFS	Median	II,III,IV	0.606	0.270	.003	14	view →
MESO	DFS	Median	All	0.242	0.605	.007	12	view →
KICH	DFS	Median	II,III,IV	0.599	0.953	.005	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

LRRC39–UVM (OS)

Open the UVM breakdown →