LRRC39

Across TCGA cell cohorts, LRRC39 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRRC39-associated genes across cancer lineages are TSPY2, FAM71B, and OR7A17. Each is linked with LRRC39 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC39-to-partner and partner-to-LRRC39 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSPY2 grouped by LRRC39-low versus LRRC39-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC39→partner) and Y-score (partner→LRRC39) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TSPY2 →	+0.078	+5.217	<.001	<.001	3	1
LARGE_INTESTINE	FAM71B →	+0.005	+5.022	<.001	.002	3	1
LARGE_INTESTINE	OR7A17 →	+0.009	+4.415	<.001	.007	3	1
LARGE_INTESTINE	PATE4 →	+0.041	+4.095	<.001	.009	3	1
LARGE_INTESTINE	UBTFL1 →	+0.017	+4.415	<.001	.007	3	1
LARGE_INTESTINE	SCYGR10 →	+0.123	+4.273	.009	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

TSPY2 by LRRC39 expression — LARGE_INTESTINE

Explore this box plot interactively →