LRRC38

Across TCGA patient cohorts, LRRC38 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,120 significant associations in total. STAD shows the largest number of these associations.

The most reproducible LRRC38-associated GO terms across cancer lineages are Regulation of heart morphogenesis, Regulation of extracellular matrix disassembly, and Regulation of osteoblast differentiation. Each is linked with LRRC38 in more than 12 cancer types. Because this analysis shows association rather than direction, both LRRC38-to-partner and partner-to-LRRC38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of heart morphogenesis grouped by LRRC38-low versus LRRC38-high in ACC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC38→partner) and Y-score (partner→LRRC38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	Regulation of heart morphogenesis →	+0.062	+1.908	<.001	<.001	3	13
STAD	Regulation of extracellular matrix disassembly →	+0.063	+0.124	<.001	<.001	3	13
STAD	Regulation of osteoblast differentiation →	+0.051	+0.148	<.001	<.001	3	13
ESCA	Chondroitin sulfate biosynthetic process →	+0.086	+0.625	<.001	<.001	3	12
STAD	Negative regulation of developmental growth →	+0.038	+0.111	<.001	<.001	3	12
ESCA	Chondroitin sulfate proteoglycan biosynthetic process →	+0.076	+0.676	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,120 associations by consensus.

Regulation of heart morphogenesis by LRRC38 expression — ACC

Explore this box plot interactively →