LRRC38

Across TCGA cell cohorts, LRRC38 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,454 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LRRC38-associated GO terms across cancer lineages are Positive regulation of voltage-gated potassium channel activity, Cellular response to ATP, and Positive regulation of membrane permeability. Each is linked with LRRC38 in more than 3 cancer types. Because this analysis shows association rather than direction, both LRRC38-to-partner and partner-to-LRRC38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of voltage-gated potassium channel activity grouped by LRRC38-low versus LRRC38-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC38→partner) and Y-score (partner→LRRC38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Positive regulation of voltage-gated potassium channel activity →	+1.112	+2.108	.002	.006	2	4
BONE	Cellular response to ATP →	+0.102	+0.145	.001	.004	3	3
BLOOD_Leukemia	Positive regulation of membrane permeability →	+0.103	+1.253	<.001	<.001	3	3
BLOOD_Leukemia	Fusion of virus membrane with host plasma membrane →	-0.637	-0.867	<.001	.002	3	3
BLOOD_Leukemia	Positive regulation of chromosome organization →	+0.045	+0.663	<.001	.002	3	3
BLOOD_Leukemia	Microtubule anchoring at centrosome →	+0.057	+0.915	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,454 associations by consensus.

Positive regulation of voltage-gated potassium channel activity by LRRC38 expression — BLOOD_Myeloma

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