LRRC38

Across TCGA cell cohorts, LRRC38 mutation is significantly associated with the RNA expression of many other genes, with 70 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRRC38-associated genes across cancer lineages are C10orf53, PLA2G3, and TAB1. Each is linked with LRRC38 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC38-to-partner and partner-to-LRRC38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C10orf53 grouped by LRRC38-low versus LRRC38-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC38→partner) and Y-score (partner→LRRC38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	C10orf53 →	+0.023	+4.906	<.001	.006	3	2
LARGE_INTESTINE	PLA2G3 →	+1.361	+3.347	<.001	.005	3	1
LARGE_INTESTINE	TAB1 →	+0.674	+3.067	.002	.009	3	1
LARGE_INTESTINE	TNRC6B →	+1.173	+3.064	<.001	.009	3	1
LARGE_INTESTINE	MT4 →	+2.078	+2.819	<.001	.006	3	1
LARGE_INTESTINE	RAI1 →	+0.831	+3.064	.006	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

C10orf53 by LRRC38 expression — OESOPHAGUS

Explore this box plot interactively →