LRRC37A3

Across TCGA patient cohorts, LRRC37A3 mutation is significantly associated with the RNA expression of many other genes, with 2,686 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC37A3-associated genes across cancer lineages are MRPS27, ZWINT, and MED9. Each is linked with LRRC37A3 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRRC37A3-to-partner and partner-to-LRRC37A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPS27 grouped by LRRC37A3-low versus LRRC37A3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC37A3→partner) and Y-score (partner→LRRC37A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPS27 →	+0.407	+2.191	<.001	.001	3	3
UCEC	ZWINT →	+0.566	+1.688	.001	.001	3	3
UCEC	MED9 →	+0.218	+2.048	.008	.001	3	3
UCEC	COX15 →	+0.341	+2.078	.001	<.001	3	3
UCEC	SUPV3L1 →	+0.266	+3.129	.008	<.001	3	3
SKCM	PPP2R2D →	+0.353	+1.768	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,686 associations by consensus.

MRPS27 by LRRC37A3 expression — UCEC

Explore this box plot interactively →