LRRC37A3

Across TCGA pan-cancer cohorts, LRRC37A3 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated LRRC37A3 data layer compared with 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher LRRC37A3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LRRC37A3 expression acts as an unfavorable survival marker, although some lineages such as PAAD and LUSC show a favorable association.

LUAD, PAAD, and KIRC are the cancer types where LRRC37A3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.742	0.878	<.001	110	view →
PAAD	OS	Median	All	0.522	0.259	<.001	73	view →
KIRC	DFS	Quartile	All	0.567	0.712	.009	64	view →
LGG	DFS	Median	All	0.779	0.885	<.001	36	view →
KIRP	DFS	Tertile	All	0.578	0.856	.002	23	view →
LUSC	OS	Median	All	0.724	0.586	.002	21	view →
UVM	DFS	Tertile	III,IV	0.252	0.791	.006	20	view →
BRCA	OS	Tertile	IV	0.711	0.281	.019	16	view →
SCLC	DFS	Median	II,III,IV	0.774	0.249	.015	12	view →
CHOL	DFS	Median	All	0.727	0.227	.012	12	view →
READ	OS	Quartile	III,IV	0.791	0.420	.012	10	view →
PRAD	DFS	Median	All	0.735	0.821	.008	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

LRRC37A3–LUAD (DFS)

Open the LUAD breakdown →