LRRC36

Across TCGA patient cohorts, LRRC36 mutation is significantly associated with the RNA expression of many other genes, with 3,078 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC36-associated genes across cancer lineages are SEPTIN7P4, C18orf54, and MBD2. Each is linked with LRRC36 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRRC36-to-partner and partner-to-LRRC36 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEPTIN7P4 grouped by LRRC36-low versus LRRC36-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC36→partner) and Y-score (partner→LRRC36) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SEPTIN7P4 →	+0.052	+3.175	.009	.004	3	3
UCEC	C18orf54 →	+0.629	+2.392	<.001	<.001	3	3
UCEC	MBD2 →	+0.385	+2.042	.005	.001	3	3
UCEC	SPATA5 →	+0.456	+2.403	<.001	<.001	3	3
UCEC	EMC3-AS1 →	+0.435	+2.330	.003	.003	3	2
UCEC	POLR2A →	+0.547	+3.491	.005	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,078 associations by consensus.

SEPTIN7P4 by LRRC36 expression — UCEC

Explore this box plot interactively →