LRRC36

Across TCGA pan-cancer cohorts, LRRC36 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of LRRC36’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where LRRC36 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LRRC36 is over-expressed in tumor, although a few such as LUAD and KICH show the opposite, repressed pattern.

COAD, LUAD, and KIRC are the cancer types where LRRC36 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LRRC36 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+1.398	<.001	12	view →
LUAD	Female	III,IV	−3.561	<.001	11	view →
KIRC	Female	All	+0.708	<.001	11	view →
KICH	Female	II,III,IV	−0.587	<.001	10	view →
LUSC	Female	II,III,IV	−3.785	<.001	9	view →
KIRP	All	All	+0.595	<.001	6	view →
STAD	All	All	+0.470	.005	4	view →
BRCA	All	All	+0.183	.002	4	view →
LIHC	All	All	+0.158	.006	4	view →
READ	All	All	+1.431	.001	2	view →
CHOL	All	All	+0.885	.001	2	view →
PRAD	All	All	+0.111	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

LRRC36–COAD

Open the COAD breakdown →