LRRC24

Across TCGA cell cohorts, LRRC24 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRRC24-associated genes across cancer lineages are HHLA1, OR1D4, and IFNA14. Each is linked with LRRC24 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC24-to-partner and partner-to-LRRC24 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HHLA1 grouped by LRRC24-low versus LRRC24-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC24→partner) and Y-score (partner→LRRC24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HHLA1 →	+0.011	+4.551	<.001	.004	3	1
BLOOD_Leukemia	OR1D4 →	+0.046	+4.539	<.001	.007	3	1
OVARY	IFNA14 →	+0.022	+5.196	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR52N5 →	+0.171	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR56B1 →	+0.048	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR6C70 →	+0.486	+6.266	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

HHLA1 by LRRC24 expression — BLOOD_Leukemia

Explore this box plot interactively →