LRRC14

Across TCGA cell cohorts, LRRC14 mutation is significantly associated with the RNA expression of many other genes, with 519 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRRC14-associated genes across cancer lineages are OR6T1, OR6M1, and EIF3L. Each is linked with LRRC14 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC14-to-partner and partner-to-LRRC14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6T1 grouped by LRRC14-low versus LRRC14-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC14→partner) and Y-score (partner→LRRC14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	OR6T1 →	+0.084	+4.285	<.001	.007	3	1
STOMACH	OR6M1 →	+0.050	+4.285	<.001	.007	3	1
LARGE_INTESTINE	EIF3L →	+0.561	+3.364	.001	.002	3	1
LARGE_INTESTINE	RBFA →	+0.852	+3.087	<.001	.006	3	1
LARGE_INTESTINE	RNF125 →	+1.051	+3.364	<.001	.002	3	1
LARGE_INTESTINE	IL7 →	+1.010	+3.451	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 519 associations by consensus.

OR6T1 by LRRC14 expression — STOMACH

Explore this box plot interactively →