LRRC14

Across TCGA pan-cancer cohorts, LRRC14 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of LRRC14’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where LRRC14 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LRRC14 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

COAD, HNSC, and LIHC are the cancer types where LRRC14 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LRRC14 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+1.105	<.001	12	view →
HNSC	All	III,IV	+0.716	<.001	12	view →
LIHC	Male	II,III,IV	+1.903	<.001	9	view →
THCA	Male	III,IV	−0.921	<.001	9	view →
STAD	Male	II,III,IV	+1.119	<.001	8	view →
LUAD	All	All	+0.342	<.001	7	view →
LUSC	Male	II,III,IV	+0.688	<.001	6	view →
BRCA	All	II,III,IV	+0.348	<.001	6	view →
CHOL	All	All	+2.286	<.001	5	view →
ESCA	All	All	+0.517	.021	4	view →
READ	All	All	+0.808	.001	2	view →
BLCA	All	All	+0.406	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

LRRC14–COAD

Open the COAD breakdown →