LRR1

Across TCGA patient cohorts, LRR1 mutation is significantly associated with the RNA expression of many other genes, with 1,520 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRR1-associated genes across cancer lineages are POLR2DP1, MRPS18BP2, and SFPQP1. Each is linked with LRR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRR1-to-partner and partner-to-LRR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POLR2DP1 grouped by LRR1-low versus LRR1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRR1→partner) and Y-score (partner→LRR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	POLR2DP1 →	+0.237	+4.081	.002	.004	3	2
COAD	MRPS18BP2 →	+0.203	+4.681	.004	.001	3	2
BRCA	SFPQP1 →	+0.021	+4.971	<.001	.005	3	2
UCEC	RNA5SP411 →	+1.316	+2.393	<.001	.002	3	2
BLCA	TRAJ43 →	+1.154	+5.588	<.001	.004	3	2
BLCA	TRAJ21 →	+0.663	+5.497	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,520 associations by consensus.

POLR2DP1 by LRR1 expression — COAD

Explore this box plot interactively →