LRP2

Across TCGA cell cohorts, LRP2 mutation is significantly associated with the RNA expression of many other genes, with 1,829 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRP2-associated genes across cancer lineages are PARD6G, ZBTB8A, and NDEL1. Each is linked with LRP2 in more than 4 cancer types. Because this analysis shows association rather than direction, both LRP2-to-partner and partner-to-LRP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PARD6G grouped by LRP2-low versus LRP2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRP2→partner) and Y-score (partner→LRP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PARD6G →	+0.957	+1.780	<.001	<.001	3	4
LARGE_INTESTINE	ZBTB8A →	+0.719	+2.113	<.001	<.001	3	4
OVARY	NDEL1 →	+0.665	+2.459	<.001	.009	3	4
STOMACH	NUP54 →	+0.524	+3.655	<.001	<.001	3	4
LUNG_NSCLC_LUAD	HAPLN4 →	+0.084	+1.811	.006	<.001	3	4
LUNG_NSCLC_LUAD	RFC1 →	+0.420	+3.321	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,829 associations by consensus.

PARD6G by LRP2 expression — LARGE_INTESTINE

Explore this box plot interactively →