LRP2

Across TCGA pan-cancer cohorts, LRP2 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of LRP2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where LRP2 RNA is repressed in tumor relative to normal tissue. In most cancer types LRP2 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and LUAD are the cancer types where LRP2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LRP2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	III,IV	−4.278	<.001	11	view →
THCA	Male	III,IV	−3.892	<.001	11	view →
LUAD	Male	II,III,IV	−2.062	<.001	10	view →
KIRC	All	All	+1.243	<.001	8	view →
COAD	All	All	+0.012	<.001	7	view →
LUSC	Male	All	−2.011	<.001	6	view →
BRCA	Female	II,III,IV	−0.819	.008	4	view →
UCEC	All	All	+0.903	.019	2	view →
PRAD	All	All	−0.116	.003	2	view →
BLCA	Male	III,IV	+0.125	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

LRP2–KICH

Open the KICH breakdown →