LRP11

Across TCGA patient cohorts, LRP11 mutation is significantly associated with the RNA expression of many other genes, with 2,187 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRP11-associated genes across cancer lineages are RNU6-391P, TTTY2, and RN7SL134P. Each is linked with LRP11 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRP11-to-partner and partner-to-LRP11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-391P grouped by LRP11-low versus LRP11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRP11→partner) and Y-score (partner→LRP11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-391P →	+0.214	+3.153	<.001	.006	3	3
LUSC	TTTY2 →	+0.009	+7.924	<.001	.008	3	3
UCEC	RN7SL134P →	+0.137	+2.751	.001	.002	3	2
HNSC	COMMD4P2 →	+0.142	+4.505	<.001	.009	3	1
HNSC	MIR1915 →	+0.649	+5.401	<.001	.001	3	1
HNSC	MTND4P27 →	+0.051	+4.736	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,187 associations by consensus.

RNU6-391P by LRP11 expression — UCEC

Explore this box plot interactively →