LRIG1

Across TCGA patient cohorts, LRIG1 mutation is significantly associated with the RNA expression of many other genes, with 3,224 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRIG1-associated genes across cancer lineages are RNA5SP389, UBE2L3, and MTFP1. Each is linked with LRIG1 in more than 3 cancer types. Because this analysis shows association rather than direction, both LRIG1-to-partner and partner-to-LRIG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP389 grouped by LRIG1-low versus LRIG1-high in GBM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRIG1→partner) and Y-score (partner→LRIG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RNA5SP389 →	+0.511	+4.754	.001	.003	3	4
SKCM	UBE2L3 →	+0.363	+3.944	<.001	<.001	3	4
SKCM	MTFP1 →	+0.607	+2.267	<.001	.001	3	3
UCEC	ZNF662 →	-0.432	-1.560	.003	.002	3	3
UCEC	KMT5A →	+0.287	+1.584	.001	.001	3	3
SKCM	UQCR10 →	+0.444	+3.398	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,224 associations by consensus.

RNA5SP389 by LRIG1 expression — GBM

Explore this box plot interactively →