LRIG1

Across TCGA pan-cancer cohorts, LRIG1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of LRIG1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where LRIG1 RNA is repressed in tumor relative to normal tissue. In most cancer types LRIG1 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

THCA, KIRC, and KIRP are the cancer types where LRIG1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LRIG1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−2.165	<.001	11	view →
KIRC	Female	All	+0.744	<.001	11	view →
KIRP	Female	All	+0.981	<.001	9	view →
LUAD	All	III,IV	−0.826	<.001	8	view →
BLCA	Male	III,IV	−1.895	.021	5	view →
READ	All	All	−1.323	.001	5	view →
LUSC	All	All	−0.559	<.001	5	view →
BRCA	Female	All	−0.474	<.001	4	view →
CHOL	All	II,III,IV	+1.810	.049	2	view →
PRAD	All	All	+1.347	<.001	2	view →
STAD	Female	All	−1.248	.038	2	view →
KICH	All	II,III,IV	+0.596	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

LRIG1–THCA

Open the THCA breakdown →