LRCH1

Across TCGA cell cohorts, LRCH1 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRCH1-associated genes across cancer lineages are MS4A13, OR4C12, and OR4M2. Each is linked with LRCH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRCH1-to-partner and partner-to-LRCH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MS4A13 grouped by LRCH1-low versus LRCH1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRCH1→partner) and Y-score (partner→LRCH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MS4A13 →	+0.325	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR4C12 →	+0.022	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR4M2 →	+0.267	+4.887	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	PPP1R2C →	+0.022	+4.736	<.001	.009	3	1
LUNG_SCLC	KCNG4 →	+0.536	+4.044	<.001	.009	3	1
LUNG_SCLC	PRAMEF10 →	+0.885	+4.643	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

MS4A13 by LRCH1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →