LRCH1

Across TCGA pan-cancer cohorts, LRCH1 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated LRCH1 data layer compared with 9 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher LRCH1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated LRCH1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and BRCA show a favorable association.

KIRC, BLCA, and CESC are the cancer types where LRCH1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.727	0.538	<.001	124	view →
BLCA	OS	Quartile	All	0.288	0.549	<.001	95	view →
CESC	OS	Quartile	All	0.460	0.819	.002	58	view →
LGG	OS	Median	All	0.743	0.874	<.001	50	view →
BRCA	DFS	Median	III,IV	0.590	0.348	.001	32	view →
THYM	DFS	Tertile	II,III,IV	0.854	0.461	.001	31	view →
LUSC	OS	Median	All	0.309	0.487	.001	26	view →
OV	OS	Quartile	All	0.236	0.363	.004	20	view →
MESO	OS	Median	All	0.294	0.475	.006	19	view →
UVM	DFS	Tertile	All	0.247	0.630	.021	16	view →
KICH	OS	Quartile	All	0.613	1.000	.008	15	view →
ACC	DFS	Tertile	All	0.565	0.859	.007	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

LRCH1–KIRC (OS)

Open the KIRC breakdown →