LPCAT4

Across TCGA patient cohorts, LPCAT4 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LPCAT4-associated genes across cancer lineages are Rab25, C-Raf, and Heregulin. Each is linked with LPCAT4 in more than 1 cancer types. Because this analysis shows association rather than direction, both LPCAT4-to-partner and partner-to-LPCAT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rab25 grouped by LPCAT4-low versus LPCAT4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LPCAT4→partner) and Y-score (partner→LPCAT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rab25 →	-0.471	-1.906	<.001	.016	3	2
UCEC	C-Raf →	+0.152	+2.700	.008	.006	3	2
SKCM	Heregulin →	+0.178	+3.012	.038	.018	3	1
UCEC	INPP4B →	-0.262	-3.584	.044	.002	3	1
UCEC	Ku80 →	+0.196	+2.428	.039	.002	3	1
UCEC	mTOR_pS2448 →	-0.140	-2.986	.019	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Rab25 by LPCAT4 expression — UCEC

Explore this box plot interactively →