LNX1

Across TCGA cell cohorts, LNX1 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LNX1-associated genes across cancer lineages are FAM47B, SMR3B, and OR52E4. Each is linked with LNX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LNX1-to-partner and partner-to-LNX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM47B grouped by LNX1-low versus LNX1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LNX1→partner) and Y-score (partner→LNX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	FAM47B →	+0.016	+5.029	<.001	.006	3	1
BLOOD_Leukemia	SMR3B →	+0.034	+4.922	<.001	.009	3	1
BLOOD_Leukemia	OR52E4 →	+0.029	+5.201	<.001	.006	3	1
BLOOD_Leukemia	KRTAP12-3 →	+0.124	+5.539	<.001	.003	3	1
CNS	FGF3 →	+0.043	+4.981	<.001	.008	3	1
LUNG_NSCLC_LUAD	CCDC172 →	+0.076	+4.544	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

FAM47B by LNX1 expression — LUNG_SCLC

Explore this box plot interactively →