LNX1

Across TCGA pan-cancer cohorts, LNX1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of LNX1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LNX1 RNA is repressed in tumor relative to normal tissue. In most cancer types LNX1 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and HNSC are the cancer types where LNX1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LNX1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	−1.571	<.001	12	view →
KIRP	Male	II,III,IV	−2.216	<.001	9	view →
HNSC	All	All	−0.761	.001	6	view →
LUSC	Female	All	+1.436	<.001	5	view →
LIHC	Female	II,III,IV	+0.766	.009	4	view →
LUAD	All	All	+0.400	<.001	3	view →
CHOL	All	All	+1.225	.001	2	view →
ESCA	All	All	−0.821	.019	2	view →
KICH	All	All	−0.636	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

LNX1–KIRC

Open the KIRC breakdown →