lncRNA neighboring enhancer of FOXA2Genealiases: LINC01384 · lncRNA-NEF
Q-omics provides the consensus-scored LNCNEF profile across patient tissues and cancer cell-line models. LNCNEF expression is associated with patient survival in 13 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, LNCNEF is differentially expressed in 2, with the highest sampling consensus in THCA. Additionally, LNCNEF RNA expression shows 7,658 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight ACC, THCA, and TGCT as cancer lineages where LNCNEF shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for LNCNEF — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes LNCNEF survival associations across molecular data types. LNCNEF RNA expression shows survival associations in the most cancer types (13). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible LNCNEF RNA expression–survival associations across cancer types. High LNCNEF expression shows unfavorable associations in ACC, LUSC, KIRC, THYM, LAML and SKCM. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .003). Together, the overview and detailed table identify ACC as the clearest survival context for LNCNEF RNA expression.
This table summarizes LNCNEF tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 2. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for LNCNEF. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. LNCNEF shows lower tumor expression in THCA and higher tumor expression in LIHC. The THCA box plot shows higher LNCNEF RNA expression in normal versus tumor tissue (log2 FC = −3.187, t-test p < 0.001).
This table shows molecular features associated with LNCNEF in patient tissues and cancer cell lines. In patient samples, LNCNEF shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set.
