LMX1A

Across TCGA patient cohorts, LMX1A RNA expression is significantly associated with the go_rna of many other GO terms, with 6,867 significant associations in total. THCA shows the largest number of these associations.

The most reproducible LMX1A-associated GO terms across cancer lineages are Neural tube patterning, Digestive system development, and Regulation of microtubule cytoskeleton organization. Each is linked with LMX1A in more than 14 cancer types. Because this analysis shows association rather than direction, both LMX1A-to-partner and partner-to-LMX1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Neural tube patterning grouped by LMX1A-low versus LMX1A-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LMX1A→partner) and Y-score (partner→LMX1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Neural tube patterning →	+0.056	+0.295	<.001	.001	3	15
STAD	Digestive system development →	+0.072	+0.173	<.001	<.001	3	13
STAD	Regulation of microtubule cytoskeleton organization →	+0.062	+0.268	<.001	.001	2	14
UCS	Eye morphogenesis →	+0.049	+1.215	<.001	.001	3	13
STAD	Mesenchymal cell differentiation →	+0.071	+0.159	<.001	<.001	3	12
STAD	Regulation of canonical Wnt signaling pathway →	+0.050	+0.157	<.001	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,867 associations by consensus.

Neural tube patterning by LMX1A expression — STAD

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