LMX1A

Across TCGA pan-cancer cohorts, LMX1A RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of LMX1A’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where LMX1A RNA is repressed in tumor relative to normal tissue. In most cancer types LMX1A is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

COAD, THCA, and BLCA are the cancer types where LMX1A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LMX1A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	−0.526	<.001	11	view →
THCA	All	II,III,IV	−0.226	<.001	10	view →
BLCA	Male	IV	−0.747	<.001	7	view →
HNSC	All	III,IV	−0.148	.007	7	view →
BRCA	Female	II,III,IV	−0.614	<.001	6	view →
READ	All	All	−0.667	<.001	3	view →
PRAD	All	All	−0.031	.010	2	view →
LUSC	Male	All	+0.223	.036	1	view →
KIRP	All	All	−0.009	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

LMX1A–COAD

Open the COAD breakdown →