LMX1A

Across TCGA pan-cancer cohorts, LMX1A RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated LMX1A data layer compared with 6 for mutation status.

The strongest signal is observed in brain lower grade glioma (LGG), where higher LMX1A RNA is associated with better overall survival. In most high-consensus cancer types, elevated LMX1A expression acts as an unfavorable survival marker, although some lineages such as LGG and SCLC show a favorable association.

LGG, SCLC, and COAD are the cancer types where LMX1A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.908	0.712	<.001	54	view →
SCLC	OS	Tertile	All	0.954	0.658	.011	48	view →
COAD	OS	Median	III,IV	0.669	0.880	.001	46	view →
PAAD	OS	Median	II,III,IV	0.675	0.491	.002	39	view →
ACC	DFS	Tertile	III,IV	0.046	0.670	.001	39	view →
MESO	OS	Tertile	II,III,IV	0.172	0.347	.016	36	view →
KIRP	OS	Tertile	All	0.388	0.759	<.001	36	view →
CHOL	DFS	Tertile	All	0.877	0.298	.007	18	view →
TGCT	DFS	Tertile	All	0.486	0.844	.002	18	view →
BLCA	DFS	Tertile	All	0.246	0.475	.023	16	view →
THYM	OS	Median	All	0.889	1.000	.018	15	view →
THCA	OS	Quartile	All	0.887	1.000	.024	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

LMX1A–LGG (OS)

Open the LGG breakdown →