LMX1A

Across TCGA patient cohorts, LMX1A mutation is significantly associated with the RNA expression of many other genes, with 3,455 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LMX1A-associated genes across cancer lineages are UHRF1, CDCA2, and FANCA. Each is linked with LMX1A in more than 3 cancer types. Because this analysis shows association rather than direction, both LMX1A-to-partner and partner-to-LMX1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UHRF1 grouped by LMX1A-low versus LMX1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMX1A→partner) and Y-score (partner→LMX1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UHRF1 →	+0.791	+1.958	<.001	<.001	3	4
UCEC	CDCA2 →	+0.707	+2.524	<.001	<.001	3	4
UCEC	FANCA →	+0.671	+2.536	<.001	<.001	3	4
SKCM	BCCIP →	+0.480	+2.515	<.001	<.001	3	4
STAD	ZWINT →	+0.705	+3.346	.008	.004	3	4
STAD	DHFR →	+0.619	+3.492	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,455 associations by consensus.

UHRF1 by LMX1A expression — UCEC

Explore this box plot interactively →