LMX1A

Across TCGA cell cohorts, LMX1A RNA expression is significantly associated with the go_rna of many other GO terms, with 1,321 significant associations in total. BONE shows the largest number of these associations.

The most reproducible LMX1A-associated GO terms across cancer lineages are Adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway, Nuclear receptor-mediated signaling pathway, and Nuclear receptor-mediated steroid hormone signaling pathway. Each is linked with LMX1A in more than 3 cancer types. Because this analysis shows association rather than direction, both LMX1A-to-partner and partner-to-LMX1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway grouped by LMX1A-low versus LMX1A-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LMX1A→partner) and Y-score (partner→LMX1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway →	+1.723	+1.299	<.001	<.001	3	4
BONE	Nuclear receptor-mediated signaling pathway →	-0.065	-1.301	<.001	<.001	3	4
BONE	Nuclear receptor-mediated steroid hormone signaling pathway →	-0.085	-1.115	<.001	.007	3	4
BONE	Steroid hormone receptor signaling pathway →	-0.085	-1.115	<.001	.007	3	4
LUNG_SCLC	Regulation of cellular response to growth factor stimulus →	-0.036	-0.244	<.001	.002	3	3
BONE	Negative regulation of cell-substrate adhesion →	-0.118	-1.196	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,321 associations by consensus.

Adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway by LMX1A expression — BONE

Explore this box plot interactively →