LMX1A

Across TCGA cell cohorts, LMX1A mutation is significantly associated with the RNA expression of many other genes, with 87 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LMX1A-associated genes across cancer lineages are IFNA2, SPATA31A1, and PRSS58. Each is linked with LMX1A in more than 1 cancer types. Because this analysis shows association rather than direction, both LMX1A-to-partner and partner-to-LMX1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNA2 grouped by LMX1A-low versus LMX1A-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMX1A→partner) and Y-score (partner→LMX1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	IFNA2 →	+0.023	+5.000	<.001	.006	3	1
PANCREAS	SPATA31A1 →	+0.006	+5.614	<.001	.002	3	1
PANCREAS	PRSS58 →	+0.092	+5.000	<.001	.006	3	1
LUNG_SCLC	MYL2 →	+0.237	+4.269	<.001	.005	3	1
LUNG_SCLC	NEU2 →	+0.015	+4.643	<.001	.004	3	1
LUNG_SCLC	IL36A →	+0.020	+4.643	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 87 associations by consensus.

IFNA2 by LMX1A expression — PANCREAS

Explore this box plot interactively →