LMO3

Across TCGA patient cohorts, LMO3 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LMO3-associated genes across cancer lineages are EGFR_pY1068, Notch1, and PCNA. Each is linked with LMO3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LMO3-to-partner and partner-to-LMO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by LMO3-low versus LMO3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMO3→partner) and Y-score (partner→LMO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.240	-2.807	.028	.003	3	1
UCEC	Notch1 →	+0.153	+3.009	.013	.019	3	1
UCEC	PCNA →	+0.245	+2.807	.009	.003	3	1
UCEC	Shc_pY317 →	-0.159	-2.115	.016	.019	3	1
UCEC	Caspase-7-cleavedD198 →	+0.576	+2.827	.026	.035	3	1
UCEC	4E-BP1 →	+0.279	+2.199	.018	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

EGFR_pY1068 by LMO3 expression — UCEC

Explore this box plot interactively →