Q-omics provides the consensus-scored LMNB1-DT profile across patient tissues and cancer cell-line models. LMNB1-DT expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, LMNB1-DT is differentially expressed in 9, with the highest sampling consensus in BRCA. Additionally, LMNB1-DT RNA expression shows 11,281 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight HNSC, BRCA, and ACC as cancer lineages where LMNB1-DT shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for LMNB1-DT — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes LMNB1-DT survival associations across molecular data types. LMNB1-DT RNA expression shows survival associations in the most cancer types (23). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible LMNB1-DT RNA expression–survival associations across cancer types. High LMNB1-DT expression shows unfavorable associations in ACC, KICH, UCEC and KIRC, but favorable associations in HNSC and MESO. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify HNSC as the clearest survival context for LMNB1-DT RNA expression.
This table summarizes LMNB1-DT tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 9. The strongest signals are observed in BRCA for RNA.
This table ranks reproducible tumor–normal expression differences for LMNB1-DT. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. LMNB1-DT shows lower tumor expression in KICH and THCA and higher tumor expression in BRCA, KIRP, LUSC and LUAD. The BRCA box plot shows higher LMNB1-DT RNA expression in tumor versus normal tissue (log2 FC = +0.070, t-test p < 0.001).
This table shows molecular features associated with LMNB1-DT in patient tissues and cancer cell lines. In patient samples, LMNB1-DT shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set.
