LMNB1-DT

Across TCGA pan-cancer cohorts, LMNB1-DT RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated LMNB1-DT data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher LMNB1-DT RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated LMNB1-DT expression acts as an unfavorable survival marker, although some lineages such as HNSC and MESO show a favorable association.

HNSC, ACC, and MESO are the cancer types where LMNB1-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	IV	0.776	0.573	<.001	94	view →
ACC	DFS	Tertile	All	0.243	0.747	<.001	69	view →
MESO	DFS	Median	IV	0.578	0.189	<.001	51	view →
KICH	OS	Tertile	III,IV	0.162	0.763	<.001	45	view →
UCEC	DFS	Median	IV	0.545	0.834	.007	38	view →
KIRC	OS	Quartile	All	0.509	0.701	<.001	32	view →
ESCA	DFS	Tertile	II,III,IV	1.000	0.213	.004	23	view →
LUAD	DFS	Tertile	II,III,IV	0.372	0.606	.007	20	view →
PRAD	DFS	Tertile	All	0.663	0.846	<.001	18	view →
THCA	OS	Quartile	III,IV	0.917	0.983	.003	16	view →
READ	OS	Tertile	IV	1.000	0.695	.017	13	view →
PAAD	OS	Median	III,IV	0.629	1.000	.022	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

LMNB1-DT–HNSC (DFS)

Open the HNSC breakdown →