LMF1

Across TCGA cell cohorts, LMF1 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LMF1-associated genes across cancer lineages are VCY1B, REG1B, and ZIC5. Each is linked with LMF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LMF1-to-partner and partner-to-LMF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VCY1B grouped by LMF1-low versus LMF1-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMF1→partner) and Y-score (partner→LMF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	VCY1B →	+1.590	+4.421	<.001	.004	3	1
BREAST	REG1B →	+0.790	+5.754	<.001	<.001	3	1
BLOOD_Leukemia	ZIC5 →	+0.466	+3.474	.005	.007	3	1
BLOOD_Leukemia	PRM3 →	+0.038	+4.247	<.001	.004	3	1
BLOOD_Leukemia	CEACAM16 →	+0.020	+4.099	<.001	<.001	3	1
LARGE_INTESTINE	STXBP3 →	+0.558	+3.067	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

VCY1B by LMF1 expression — BREAST

Explore this box plot interactively →