LMAN1L

Across TCGA patient cohorts, LMAN1L mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LMAN1L-associated genes across cancer lineages are Caspase-7-cleavedD198, Src_pY527, and eEF2. Each is linked with LMAN1L in more than 3 cancer types. Because this analysis shows association rather than direction, both LMAN1L-to-partner and partner-to-LMAN1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by LMAN1L-low versus LMAN1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMAN1L→partner) and Y-score (partner→LMAN1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.690	+1.894	.003	.030	3	4
UCEC	Src_pY527 →	-0.580	-2.700	<.001	.005	3	3
UCEC	eEF2 →	+0.284	+2.999	.043	.035	3	2
UCEC	FoxM1 →	+0.210	+2.331	.038	.019	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.470	-1.571	.007	.036	3	2
UCEC	p70-S6K_pT389 →	-0.252	-3.690	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Caspase-7-cleavedD198 by LMAN1L expression — UCEC

Explore this box plot interactively →