LIX1

Across TCGA patient cohorts, LIX1 mutation is significantly associated with the RNA expression of many other genes, with 1,416 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIX1-associated genes across cancer lineages are MIR6718, USP17L3, and RNU4-58P. Each is linked with LIX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LIX1-to-partner and partner-to-LIX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6718 grouped by LIX1-low versus LIX1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIX1→partner) and Y-score (partner→LIX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR6718 →	+0.122	+3.990	.005	.009	3	2
BLCA	USP17L3 →	+0.019	+7.640	<.001	.009	3	2
UCEC	RNU4-58P →	+0.217	+2.548	.001	.007	3	2
UCEC	TRAJ58 →	+0.391	+2.351	<.001	.006	3	2
UCEC	IGHD6-19 →	+0.541	+2.835	<.001	.003	3	2
UCEC	ACTR3P2 →	+0.189	+3.097	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,416 associations by consensus.

MIR6718 by LIX1 expression — SKCM

Explore this box plot interactively →