LIX1

Across TCGA pan-cancer cohorts, LIX1 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated LIX1 data layer compared with 1 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher LIX1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated LIX1 expression acts as an unfavorable survival marker, although some lineages such as KIRP and PRAD show a favorable association.

MESO, ACC, and UCEC are the cancer types where LIX1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Quartile	All	0.175	0.467	.003	73	view →
ACC	OS	Quartile	All	0.742	0.938	.005	70	view →
UCEC	DFS	Tertile	All	0.528	0.812	.002	66	view →
KIRP	DFS	Median	All	1.000	0.788	.001	46	view →
SCLC	OS	Median	IV	0.219	0.729	.003	21	view →
READ	OS	Tertile	All	0.820	1.000	.017	20	view →
PRAD	DFS	Median	All	0.877	0.679	<.001	18	view →
KIRC	DFS	Quartile	All	0.857	0.760	.025	16	view →
THYM	DFS	Quartile	All	0.705	1.000	.002	16	view →
CHOL	DFS	Quartile	II,III,IV	1.000	0.152	.017	15	view →
LGG	DFS	Quartile	All	0.818	0.581	<.001	15	view →
THCA	DFS	Quartile	All	0.886	0.713	.007	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

LIX1–MESO (OS)

Open the MESO breakdown →