LIPM

Across TCGA patient cohorts, LIPM mutation is significantly associated with the RNA expression of many other genes, with 1,263 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIPM-associated genes across cancer lineages are MIR5708, RPS10-NUDT3, and IGHV3OR16-6. Each is linked with LIPM in more than 1 cancer types. Because this analysis shows association rather than direction, both LIPM-to-partner and partner-to-LIPM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR5708 grouped by LIPM-low versus LIPM-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIPM→partner) and Y-score (partner→LIPM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR5708 →	+0.683	+7.924	<.001	.008	3	2
UCEC	RPS10-NUDT3 →	+0.272	+2.183	<.001	.005	3	1
UCEC	IGHV3OR16-6 →	+0.380	+2.610	.006	<.001	3	1
UCEC	IGKV1OR2-118 →	+0.213	+2.633	<.001	<.001	3	1
UCEC	IGHV3OR16-8 →	+0.607	+2.950	.002	<.001	3	1
UCEC	IGKV1OR2-6 →	+0.784	+2.810	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,263 associations by consensus.

MIR5708 by LIPM expression — LUSC

Explore this box plot interactively →