LIPM

Across TCGA pan-cancer cohorts, LIPM RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of LIPM’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where LIPM RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LIPM is over-expressed in tumor, although a few such as KIRP and HNSC show the opposite, repressed pattern.

THCA, LUAD, and KIRP are the cancer types where LIPM tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LIPM RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	III,IV	+0.292	<.001	10	view →
LUAD	Female	II,III,IV	+1.551	<.001	9	view →
KIRP	All	II,III,IV	−0.353	<.001	9	view →
LUSC	Male	All	+0.959	<.001	6	view →
UCEC	All	All	+0.807	<.001	6	view →
STAD	Male	All	+0.740	.007	6	view →
COAD	All	II,III,IV	+0.725	<.001	6	view →
BRCA	All	III,IV	+0.721	<.001	6	view →
PAAD	Female	All	+0.674	.010	4	view →
HNSC	All	II,III,IV	−0.573	.021	4	view →
CHOL	All	All	+1.138	<.001	3	view →
READ	All	All	+0.826	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

LIPM–THCA

Open the THCA breakdown →