LIPH

Across TCGA patient cohorts, LIPH mutation is significantly associated with the RNA expression of many other genes, with 1,982 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIPH-associated genes across cancer lineages are RNU6-709P, MIR6876, and EI24P4. Each is linked with LIPH in more than 1 cancer types. Because this analysis shows association rather than direction, both LIPH-to-partner and partner-to-LIPH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-709P grouped by LIPH-low versus LIPH-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIPH→partner) and Y-score (partner→LIPH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-709P →	+0.270	+5.040	<.001	.002	3	2
LUSC	MIR6876 →	+0.585	+5.273	<.001	.006	3	2
SKCM	EI24P4 →	+0.027	+2.932	<.001	<.001	3	2
SKCM	ARPC4 →	+0.373	+2.839	.001	.001	3	2
LUAD	RNU5A-2P →	+0.300	+5.712	<.001	.003	3	2
UCEC	LAMTOR1 →	+0.317	+2.258	.007	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,982 associations by consensus.

RNU6-709P by LIPH expression — BLCA

Explore this box plot interactively →