LIPH

Across TCGA pan-cancer cohorts, LIPH RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of LIPH’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where LIPH RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LIPH is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

THCA, KIRC, and KICH are the cancer types where LIPH tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LIPH RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	+5.087	<.001	11	view →
KIRC	Male	II,III,IV	−3.294	<.001	11	view →
KICH	Male	All	−2.343	<.001	10	view →
COAD	Female	All	−1.320	<.001	9	view →
LUSC	Female	All	−2.292	<.001	7	view →
READ	All	All	−1.313	<.001	7	view →
HNSC	All	All	−0.944	.003	6	view →
CHOL	Male	All	+4.268	<.001	4	view →
BRCA	All	All	+0.615	<.001	4	view →
LIHC	All	All	+0.519	.006	3	view →
KIRP	All	All	−1.021	.003	2	view →
PRAD	All	All	+0.562	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

LIPH–THCA

Open the THCA breakdown →