LIPH

Across TCGA pan-cancer cohorts, LIPH RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated LIPH data layer compared with 3 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher LIPH RNA is associated with better overall survival. In most high-consensus cancer types, elevated LIPH expression acts as an unfavorable survival marker, although some lineages such as UVM and KICH show a favorable association.

UVM, KICH, and UCEC are the cancer types where LIPH RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	II,III,IV	0.908	0.582	.006	76	view →
KICH	OS	Tertile	III,IV	0.899	0.228	<.001	48	view →
UCEC	DFS	Median	All	0.427	0.770	<.001	44	view →
KIRC	DFS	Tertile	All	0.548	0.740	<.001	41	view →
BRCA	DFS	Quartile	All	0.490	0.723	.001	37	view →
PAAD	OS	Median	All	0.285	0.516	.001	33	view →
CESC	DFS	Quartile	III,IV	0.876	0.518	.008	28	view →
THCA	OS	Quartile	III,IV	1.000	0.863	.009	27	view →
ESCA	DFS	Median	All	0.406	0.880	.003	27	view →
PRAD	DFS	Tertile	All	0.895	0.750	.002	12	view →
LIHC	OS	Median	III,IV	0.602	0.199	.001	9	view →
SCLC	OS	Median	II,III,IV	0.477	1.000	.012	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

LIPH–UVM (OS)

Open the UVM breakdown →